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Aston Villa have to simply hold strong to make it to the UEFA Europa League quarter-finals after defeating Lille one-nil on the road.
Match Replays
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Bologna and Roma are level following a one-one draw in the opening leg in Emilia, as the guests managed to respond after going down in the score.
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Porto and Stuttgart meet in a heated second leg of the Round of 16, with the hosts having built a 2-1 advantage in the first leg in Germany.
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Real Betis return home to the Estadio La Cartuja de Sevilla, necessitating a win, since Panathinaikos came out on top with a one-nil result in Greece.
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Midtjylland just have to hold on to their lead at home to pull off an upset, having defeated Nottingham Forest one-nil in London in the first leg.
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Freiburg seek a big day at the Europa-Park Stadion to advance to the next round, since Genk narrowly prevailed in the opening bout in Belgium.
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Lyon look to exploit an away draw in the first leg of their Round of 16 matchup to secure a spot in the next phase while tangling with Celta at home.
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Braga need a strong performance in front of their crowd as they try to stage a comeback from a two-goal deficit against Ferencváros.
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Freiburg head across the Eastern border for their opening Round of 16 meeting in UEFA Europa League play, facing Genk at the Cegeka Arena.
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Lyon and Celta meet in a battle between Ligue 1 and La Liga, with first-place Lyon looking to avoid a misstep as they make the trip to Galicia.
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Ferencváros are riding high following a successful comeback in the playoff round versus Ludogorets as they prepare to lock horns with Sporting Braga.
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Midtjylland hope not to let their strong displays unravel in the knockouts, as they start battling Nottingham Forest, which just eliminated Fenerbahce.