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Freiburg head across the Eastern border for their opening Round of 16 meeting in UEFA Europa League play, facing Genk at the Cegeka Arena.
Match Replays
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Lyon and Celta meet in a battle between Ligue 1 and La Liga, with first-place Lyon looking to avoid a misstep as they make the trip to Galicia.
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Ferencváros are riding high following a successful comeback in the playoff round versus Ludogorets as they prepare to lock horns with Sporting Braga.
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Midtjylland hope not to let their strong displays unravel in the knockouts, as they start battling Nottingham Forest, which just eliminated Fenerbahce.
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Aston Villa need to recover quickly from a poor finish in league play while visiting Lille in the first match of the UEFA Europa League Round of 16.
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Familiar foes meet in the Round of 16, with Roma defying Bologna in the first leg of a matchup for Italian superiority in UEFA Europa League action.
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Porto start their bid to add a third UEFA Europa League trophy to their cabinet as they begin knockout phase action against Stuttgart at the MHPArena.
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Panathinaikos survived the playoff round via a penalty shootout, and things won't get any easier as they gear up to square off against Real Betis.
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Dinamo Zagreb have dropped four of their past five matches in the competition and have their backs against the wall after losing 3-1 to Genk at home.
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Nottingham Forest only need to avoid a major collapse to eliminate Fenerbahçe, heading back to the City Ground with a 3-1 lead in their pocket.
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Celta have the security of playing at home as they look to finish the job in the second leg of their UEFA Europa League play-off versus PAOK.
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Bologna look to defend the narrow lead they have built in Norway last week as they take on Brann at home in the second leg of their play-off contest.