Real Betis will try to lean on their home advantage to advance after the two outfits shared the spoils with a 1-1 result in Braga in the first leg.
Match Replays
Porto and Nottingham Forest are level as they gear up to meet at The City Ground with a berth in the UEFA Europa League semi-finals on the line.
Aston Villa return home searching to maintain the two-goal lead they built on the road against Bologna and punch their ticket to the semi-finals.
Freiburg look to maintain their massive 3-0 lead as they head to Spain to take on Celta for a spot in the UEFA Europa League semi-finals.
Nottingham Forest ousted Fenerbahçe and Midtjylland, while Porto defeated Stuttgart to set up this bout, which will begin at Estadio do Dragão.
Strong sides collide at the Stadio Renato Dall'Ara in the first leg of the UEFA Europa League Round of Eight, as Bologna welcome Aston Villa.
Spain and Germany meet in the UEFA Europa League quarter-finals, with Celta traveling to square off against Freiburg at the Europa-Park Stadion.
Braga bested Ferencváros and will host the first leg of their matchup against Real Betis, which eliminated Panathinaikos, in the Round of 16.
Aston Villa have to simply hold strong to make it to the UEFA Europa League quarter-finals after defeating Lille one-nil on the road.
Bologna and Roma are level following a one-one draw in the opening leg in Emilia, as the guests managed to respond after going down in the score.
Porto and Stuttgart meet in a heated second leg of the Round of 16, with the hosts having built a 2-1 advantage in the first leg in Germany.
Real Betis return home to the Estadio La Cartuja de Sevilla, necessitating a win, since Panathinaikos came out on top with a one-nil result in Greece.