Young Boys need a win to secure safety to the playoffs against Stuttgart, which can still make the top eight if they prevail and get some help.
Match Replays
Brann must avoid a disappointing ending in order not to drop out of a knockout stage spot against Strum Graz, which, instead, are already out.
Real Betis hold the eighth position only by goal differential as they visit a Feyenoord squad aiming for a victory to have a chance to advance.
Porto need a win to have a chance of automatic qualification to the Round of 16. Instead, Rangers have already been ousted heading into the last tilt.
Panathinaikos are locked into a top 24 placement as they try to upset Roma, which are looking for a win to avoid having to go through the playoffs.
Ferencváros look to earn an upset win to defend their strong position as they visit Nottingham Forest, which are stuck in the middle of the pack.
Dinamo Zagreb hope to avoid a fourth loss in five UEFA Europa League matches but will take on a tough challenge against fourth-place Midtjylland.
Maccabi Tel-Aviv will only play for pride as they are at the bottom of the standings. Bologna are almost certainly headed to the knockout stage.
Lyon reside atop the table ahead of the final match-day and secured their spot in the next phase. Instead, PAOK appear bound for the playoffs.
Nice will end a disappointing UEFA Europa League campaign trying to play spoiler against Ludogorets, which sit one point from the knockout stage.
Freiburg have their eyes on a first-place group phase spot when visiting Lille, which just need a point to avoid elimination from the competition.
Braga need a point to obtain a Round of 16 spot as they face Go Ahead Eagles away, which are in 30th position in the table and likely to exit.