Real Madrid and Inter had fairly disappointing continental campaigns, as the former exited in the quarter-finals, while the Italian side even earlier.
Match Replays
Porto didn't get past the Round of 16 in their last two participations. Man. City will try to go all the way under Maresca after a fairly early exit.
Real Betis are making their first UEFA Champions League appearance in 21 years. Lille are playing with the current format for the first time.
Both sides seek improvements, as Villarreal logged just one point in the group stage last year, while Borussia Dortmund bowed out shortly thereafter.
Club Brugge finished 19th in the group phase before being knocked out by Atletico Madrid. Aston Villa qualified by winning the UEFA Europa League.
AEK Athens eliminated Levski Sofia in the playoff to advance to the main stage. LASK pulled off the upset versus Celtic, coming back from a 3-0 loss.
The two outfits shared the spoils in a goalless draw in Bulgaria, so AEK Athens will attempt to lean on their home-field advantage to go through.
Lyon and Fenerbahçe traded blows through their stars in the first match, but neither managed to gain the upper hand ahead of the decisive meeting.
Slovan Bratislava jumped to an early lead last week, but Celje quickly replied, so the outcome of the contest will be determined in Slovenia.
The qualification hangs in the balance since the first game ended with a two-two draw, as Viking managed to dig their way out of an early hole.
Bodø/Glimt have more than one foot in the next stage of the competition after building a two-goal advantage in the first leg despite playing away.
Celtic will look to finish the job in Austria after properly routing LASK, bagging three goals without conceding, in front of their own crowd.