Barcelona have their backs against the wall as Atlético Madrid took advantage of an early red card and built a two-goal advantage at the Camp Nou.
Match Replays
PSG ran the show at the Parc des Princes, but the qualification is still open, as they squandered a few chances to round out the two-nil result.
PSG sweated more in the derby with Monaco in the playoff than versus Chelsea, which they crushed, while Liverpool tamed Galatasaray in the return leg.
La Liga rivals face off in the quarter-finals after Barcelona routed Newcastle United and Atlético Madrid topped Club Brugge and Tottenham.
Two of the top contenders meet in the Round of Eight already after Real Madrid ousted Man. City convincingly and Bayern demolished Atalanta.
Sporting CP pulled off an improbable comeback against Bodø/Glimt after losing three-nil in Norway, while Arsenal handled Bayer Leverkusen at home.
Bayern were no match for Atalanta in the opening match in Bergamo, as their attackers ran amok all game long and hung six goals on the opponents.
Tottenham gift-wrapped three early goals to the opponents because of blunders, and Atlético Madrid cruised to a 5-2 victory in Madrid.
Galatasaray came out guns blazing, thanks to the support of their crowd, hit the net early and held onto their slim advantage the rest of the way.
Newcastle United confirmed their caliber in knockout play and almost got the win at home, but Barcelona equalized at the death with a penalty kick.
Chelsea went mano-a-mano with PSG for about two/thirds of the first leg, but the reigning champions pulled away late, building a sizeable lead.
Man. City got off to a decent start at the Santiago Bernabéu, but then Federico Valverde took over the game and completed a spectacular hat-trick.