Dinamo Zagreb have dropped four of their past five matches in the competition and have their backs against the wall after losing 3-1 to Genk at home.
Match Replays
Nottingham Forest only need to avoid a major collapse to eliminate Fenerbahçe, heading back to the City Ground with a 3-1 lead in their pocket.
Celta have the security of playing at home as they look to finish the job in the second leg of their UEFA Europa League play-off versus PAOK.
Bologna look to defend the narrow lead they have built in Norway last week as they take on Brann at home in the second leg of their play-off contest.
Panathinaikos and Viktoria Plzeň enter the second leg tied 2-2, with the latter having a slight edge thanks to their home-field advantage in this one.
Stuttgart look to put away a 4-1 lead as they return home for the second leg of their UEFA Europa League playoff match-up against Celtic.
Ferencváros hope not to spoil their solid campaign so far with an early elimination, as they find themselves down 2-1 after visiting Ludogorets.
Crvena Zvezda are looking to finish a massive upset after a tight win and send Lille packing as they return home for the second tie of the play-offs.
Viktoria Plzeň are yet to lose a match in UEFA Europa League play and will look to avoid their first stumble as they defy Panathinaikos in Greece.
Ludogorets hope to carry their momentum after securing a playoff spot in the last contest of the previous stage in the first meeting with Ferencváros.
Crvena Zvezda head to France for the first bout of the playoff tie versus Lille, with the French club having won thrice and lost once at home so far.
Two of the main contenders to win the UEFA Europa League meet in Scotland in the first leg of their contest, with a Round of 16 berth on the line.