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Young Boys earned their first win last time out and will hope that form can carry them past a visiting Ludogorets side.
Match Replays
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Roma look to bounce back from a loss when they take on Viktoria Plzeň, who are flying high in the early stages of the Europa League.
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Nottingham Forest have sacked two managers this season and will be hoping for some new ideas when they host Porto, who have yet to drop points.
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Dinamo Zagreb sit atop the table with six goals scored in two matches and will hope to overwhelm Malmö, who need all three points at home.
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Maccabi Tel-Aviv play host to Midtjylland, who are looking to continue a perfect start to life in the Europa League.
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PAOK looks to pull off the upset on the road against a Lille side that have been perfect to start the Europa League.
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Utrecht travel to Germany to take on Freiburg, who are unbeaten after two matches in the league stage of the UEFA Europa League.
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Celtic have struggled of late but have the chance to turn it around when they take on Sturm Graz at home in the Europa League.
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Celta and Nice clash in what could be a crucial match for deciding the top eight places in the Europa League league phase.
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Panathinaikos look to rebound from a loss last time out when they travel to take on Feyenoord in the UEFA Europa League.
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Ferencváros and RB Salzburg are both looking for all three points to try and solidify places in the top 24 of the UEFA Europa League.
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Lyon play host to Basel in a clash between two sides with ambitions for a deep run in the Europa League knockout stage.