Ten years after a plague turns most of the world's population into vampires, a critical blood shortage causes panic and gruesome mutations among the reanimated. Edward (Ethan Hawke), a vampire hematologist, tries to develop a blood substitute when he meets Lionel (Willem Dafoe) and Audrey (Claudia Karvan), two fugitive humans who claim to have a possible cure.
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Ten years after a plague turns most of the world's population into vampires, a critical blood shortage causes panic and gruesome mutations among the reanimated. Edward (Ethan Hawke), a vampire hematologist, tries to develop a blood substitute when he meets Lionel (Willem Dafoe) and Audrey (Claudia Karvan), two fugitive humans who claim to have a possible cure.